Hunter syndrome (MPS II) is a rare, progressive disease, and there is no cure today. Operation Hunter backs every credible scientific path toward one — funding research coordination, recruiting investigators, and winning grants — and prioritizes approaches that can reach the brain, where this disease does its cruelest work.
We are the catalyst, not the clinic. Your gift funds the grunt work that helps qualified teams get to a trial faster. Donations are processed by a secure third-party platform — Operation Hunter never sees or stores your card or bank details.
These describe the kind of coordination work your gift helps fund — not medical treatment, and not any promised outcome. Gifts are unrestricted toward the mission, and amounts are approximate.
Monthly gifts give qualified teams steady, predictable support — and you can change or cancel anytime on the platform.
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Donations fund the catalyst work: screening and applying for research grants, scouting publicly-published MPS II investigators, synthesizing the scientific literature, and drafting the legal and tax structure (for a licensed attorney and CPA to sign off). Any science happens only inside qualified institutions under FDA and IRB oversight — Operation Hunter does not perform medicine.
Want the detail? See the campaign plan and our cited grant radar and financial strategy.
Payments are processed entirely by a hosted third-party donation platform. Card and bank details go directly to that platform's secure systems; they never pass through, and are never stored on, this website. We receive only the funds and the platform's standard reporting.
Operation Hunter is not yet a registered 501(c)(3) tax-exempt organization. Unless and until contributions are processed through a fiscal sponsor or a recognized tax-exempt entity, gifts are generally not tax-deductible. We are exploring fiscal sponsorship to enable deductible giving. Please consult your own tax advisor about your situation.
Thousands of companies will match an employee's donation to an eligible nonprofit — often dollar-for-dollar — yet an estimated $4–7 billion in matching funds goes unclaimed every year, per Double the Donation. If your employer has a matching-gift program, your gift could go further at no extra cost to you.
Note: employer matching generally requires the recipient to be a registered tax-exempt nonprofit. Operation Hunter is working toward that status — ask your HR or giving portal whether a gift here qualifies, and check back here for updates.
Operation Hunter supports multiple credible scientific routes toward a cure, with a priority on therapies that can cross the blood–brain barrier. One direction we find promising — an encapsulated-cell / iPSC-gene-corrected approach to delivering the IDS enzyme — is a proposed research direction only. It is not approved, not human-tested, and not proven, and it is not available as a treatment. Nothing on this page is a medical claim, a promise of any outcome, or an offer of therapy.
Background, attributed to primary sources: Hunter syndrome (mucopolysaccharidosis type II) is a rare, X-linked condition caused by a shortage of the enzyme iduronate-2-sulfatase, leading to a progressive buildup of complex sugars in the body's cells — per MedlinePlus Genetics (U.S. National Library of Medicine). There is no cure, and current care focuses on managing the disease — see the National MPS Society and our cited research library.